GALC

Across TCGA cell cohorts, GALC mutation is significantly associated with the RNA expression of many other genes, with 23 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible GALC-associated genes across cancer lineages are TBX5, GHRH, and C8orf74. Each is linked with GALC in more than 1 cancer types. Because this analysis shows association rather than direction, both GALC-to-partner and partner-to-GALC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TBX5 grouped by GALC-low versus GALC-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GALC→partner) and Y-score (partner→GALC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	TBX5 →	+0.280	+4.095	<.001	.003	3	2
OESOPHAGUS	GHRH →	+0.060	+4.906	<.001	.006	3	1
SOFT_TISSUE	C8orf74 →	+0.022	+4.369	<.001	.008	3	1
SOFT_TISSUE	TMEM207 →	+0.016	+4.369	<.001	.008	3	1
SOFT_TISSUE	BHLHA9 →	+0.027	+4.977	<.001	.002	3	1
BLOOD_Lymphoma	PRLHR →	+0.006	+4.247	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

TBX5 by GALC expression — OVARY

Explore this box plot interactively →