Across TCGA pan-cancer cohorts, GAL3ST4 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of GAL3ST4’s most consistent transcriptional readouts.
The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where GAL3ST4 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types GAL3ST4 is over-expressed in tumor, although a few such as UCEC and PRAD show the opposite, repressed pattern.
KIRC, KIRP, and LIHC are the cancer types where GAL3ST4 tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GAL3ST4 RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.