GAL3ST3

Across TCGA pan-cancer cohorts, GAL3ST3 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated GAL3ST3 data layer compared with 4 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher GAL3ST3 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated GAL3ST3 expression acts as an unfavorable survival marker, although some lineages such as HNSC and KIRP show a favorable association.

HNSC, UCEC, and KIRP are the cancer types where GAL3ST3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Quartile	All	0.543	0.272	<.001	86	view →
UCEC	OS	Median	All	0.829	0.912	<.001	60	view →
KIRP	DFS	Tertile	All	0.950	0.816	.001	53	view →
SCLC	OS	Tertile	II,III,IV	0.660	0.261	.001	32	view →
DLBC	DFS	Quartile	IV	0.146	0.731	<.001	27	view →
COAD	DFS	Tertile	IV	0.230	0.544	<.001	27	view →
BRCA	DFS	Median	IV	0.311	0.717	.003	22	view →
UVM	OS	Median	All	0.769	1.000	.009	18	view →
UCS	OS	Median	IV	0.404	0.752	.013	18	view →
LIHC	DFS	Tertile	All	0.196	0.322	.023	16	view →
THCA	DFS	Tertile	All	0.969	0.892	.016	15	view →
SKCM	DFS	Quartile	All	0.307	0.192	.001	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

GAL3ST3–HNSC (DFS)

Open the HNSC breakdown →