GAL3ST3

Across TCGA pan-cancer cohorts, GAL3ST3 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of GAL3ST3’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where GAL3ST3 RNA is repressed in tumor relative to normal tissue. In most cancer types GAL3ST3 is over-expressed in tumor, although a few such as KIRC and KICH show the opposite, repressed pattern.

KIRC, KICH, and KIRP are the cancer types where GAL3ST3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GAL3ST3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	II,III,IV	−2.695	<.001	12	view →
KICH	Male	All	−3.887	<.001	11	view →
KIRP	Male	III,IV	−2.626	<.001	11	view →
COAD	Male	II,III,IV	−0.056	<.001	8	view →
THCA	All	All	−0.545	<.001	7	view →
UCEC	All	III,IV	−2.101	.004	6	view →
LUAD	All	IV	+0.200	.009	4	view →
BRCA	All	All	−0.053	<.001	4	view →
LIHC	All	II,III,IV	+0.012	.005	4	view →
HNSC	All	All	−0.034	.018	3	view →
PRAD	All	All	−0.567	<.001	2	view →
LUSC	All	All	+0.202	.043	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

GAL3ST3–KIRC

Open the KIRC breakdown →