GAL3ST2

Across TCGA cell cohorts, GAL3ST2 mutation is significantly associated with the RNA expression of many other genes, with 22 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible GAL3ST2-associated genes across cancer lineages are MS4A5, TMEM196, and RNF133. Each is linked with GAL3ST2 in more than 1 cancer types. Because this analysis shows association rather than direction, both GAL3ST2-to-partner and partner-to-GAL3ST2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MS4A5 grouped by GAL3ST2-low versus GAL3ST2-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GAL3ST2→partner) and Y-score (partner→GAL3ST2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	MS4A5 →	+0.049	+4.384	<.001	.006	3	1
BLOOD_Leukemia	TMEM196 →	+0.042	+3.874	<.001	.005	3	1
BLOOD_Leukemia	RNF133 →	+0.057	+3.705	<.001	.007	3	1
BLOOD_Leukemia	GSG1L2 →	+0.034	+4.384	<.001	.006	3	1
BLOOD_Leukemia	PRSS50 →	+0.034	+4.066	<.001	.004	3	1
LARGE_INTESTINE	ADAMTS4 →	+0.112	+3.889	.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

MS4A5 by GAL3ST2 expression — BLOOD_Leukemia

Explore this box plot interactively →