GAL3ST2

Across TCGA pan-cancer cohorts, GAL3ST2 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of GAL3ST2’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where GAL3ST2 RNA is repressed in tumor relative to normal tissue. In most cancer types GAL3ST2 is over-expressed in tumor, although a few such as KIRC and KICH show the opposite, repressed pattern.

KIRC, STAD, and KICH are the cancer types where GAL3ST2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GAL3ST2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	All	−0.320	<.001	9	view →
STAD	Male	All	+1.370	<.001	7	view →
KICH	Male	All	−0.700	<.001	7	view →
BRCA	Female	II,III,IV	+0.849	<.001	6	view →
LUAD	All	II,III,IV	+0.399	.002	5	view →
COAD	Male	II,III,IV	−0.940	.022	4	view →
LUSC	All	All	+0.425	<.001	4	view →
KIRP	Male	All	−0.393	<.001	4	view →
LIHC	All	All	+0.256	.005	4	view →
READ	Male	All	−1.839	.035	2	view →
HNSC	Male	III,IV	+0.518	.022	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

GAL3ST2–KIRC

Open the KIRC breakdown →