GAL3ST1

Across TCGA pan-cancer cohorts, GAL3ST1 Mutation is linked to patient survival in 8 of 34 cancer types, making it a survival-associated GAL3ST1 data layer compared with 28 for mass-spec protein and 1 for mass-spec protein.

The strongest signal is observed in rectum adenocarcinoma (READ), where higher GAL3ST1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated GAL3ST1 expression acts as an unfavorable survival marker, although some lineages such as UCEC and STAD show a favorable association.

READ, DLBC, and UCEC are the cancer types where GAL3ST1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
READ	OS	Median	II,III,IV	0.173	0.818	<.001	33	view →
DLBC	DFS	Median	II,III,IV	0.065	0.829	<.001	24	view →
UCEC	DFS	Median	All	1.000	0.827	.008	22	view →
KICH	DFS	Median	All	0.102	0.848	.004	13	view →
COAD	OS	Median	All	0.124	0.809	<.001	13	view →
SARC	DFS	Median	All	0.121	0.611	.041	6	view →
LUAD	OS	Median	All	0.176	0.835	<.001	6	view →
STAD	DFS	Median	III,IV	1.000	0.366	.037	3	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

GAL3ST1–READ (OS)

Open the READ breakdown →