GAK

Across TCGA pan-cancer cohorts, GAK Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated GAK data layer compared with 24 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in kidney chromophobe (KICH), where higher GAK Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated GAK expression acts as an unfavorable survival marker, although some lineages such as UCEC and STAD show a favorable association.

KICH, UCEC, and SKCM are the cancer types where GAK Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KICH	DFS	Median	All	0.082	0.891	<.001	21	view →
UCEC	DFS	Median	All	0.954	0.828	.027	6	view →
SKCM	DFS	Median	III,IV	0.336	0.659	.024	3	view →
STAD	DFS	Median	IV	1.000	0.284	.038	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

GAK–KICH (DFS)

Open the KICH breakdown →