GAK

Across TCGA pan-cancer cohorts, GAK RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of GAK’s most consistent transcriptional readouts.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where GAK RNA is more highly expressed in tumor relative to normal tissue. In most cancer types GAK is over-expressed in tumor, although a few such as COAD and KIRP show the opposite, repressed pattern.

LIHC, COAD, and BRCA are the cancer types where GAK tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GAK RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LIHC	Female	II,III,IV	+1.121	<.001	9	view →
COAD	Female	All	−0.444	<.001	6	view →
BRCA	All	II,III,IV	+0.427	<.001	6	view →
STAD	All	All	+0.731	<.001	4	view →
KICH	All	All	+0.517	<.001	4	view →
CHOL	Male	All	+1.873	<.001	3	view →
KIRP	All	III,IV	−0.317	.014	3	view →
KIRC	Male	All	−0.223	.014	3	view →
PAAD	Male	All	+0.674	.011	2	view →
PRAD	All	All	+0.314	<.001	2	view →
BLCA	Male	III,IV	+0.538	.026	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

GAK–LIHC

Open the LIHC breakdown →