GAK

Across TCGA pan-cancer cohorts, GAK mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated GAK data layer compared with 24 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher GAK mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated GAK expression acts as an unfavorable survival marker, although some lineages such as PDAC and UCEC show a favorable association.

PDAC, UCEC, and HNSC are the cancer types where GAK mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Tertile	II,III,IV	0.516	0.264	<.001	70	view →
UCEC	DFS	Quartile	All	1.000	0.812	.003	24	view →
HNSC	DFS	Tertile	III,IV	0.889	0.286	.008	16	view →
LUAD	OS	Median	III,IV	1.000	0.663	.007	15	view →
CCRCC	DFS	Tertile	All	1.000	0.879	.016	6	view →
LSCC	DFS	Median	II,III,IV	0.664	0.882	.017	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

GAK–PDAC (DFS)

Open the PDAC breakdown →