GAK

Across TCGA cell cohorts, GAK mutation is significantly associated with the RNA expression of many other genes, with 355 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GAK-associated genes across cancer lineages are TBL1Y, CEACAM3, and MTRNR2L10. Each is linked with GAK in more than 1 cancer types. Because this analysis shows association rather than direction, both GAK-to-partner and partner-to-GAK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TBL1Y grouped by GAK-low versus GAK-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GAK→partner) and Y-score (partner→GAK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	TBL1Y →	+0.325	+3.807	.004	<.001	3	2
SOFT_TISSUE	CEACAM3 →	+0.111	+4.369	<.001	.008	3	2
BLOOD_Lymphoma	MTRNR2L10 →	+0.393	+2.691	.007	.007	3	2
CNS	BRDT →	+0.538	+3.906	<.001	.003	3	2
BLOOD_Leukemia	ASIC2 →	+0.479	+3.038	<.001	.002	3	2
BLOOD_Leukemia	C1orf185 →	+0.057	+2.450	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 355 associations by consensus.

TBL1Y by GAK expression — OESOPHAGUS

Explore this box plot interactively →