GADL1

Across TCGA patient cohorts, GADL1 mutation is significantly associated with the RNA expression of many other genes, with 1,736 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GADL1-associated genes across cancer lineages are RNU6-236P, RNU6-618P, and RPL36AP51. Each is linked with GADL1 in more than 2 cancer types. Because this analysis shows association rather than direction, both GADL1-to-partner and partner-to-GADL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-236P grouped by GADL1-low versus GADL1-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GADL1→partner) and Y-score (partner→GADL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	RNU6-236P →	+0.263	+3.370	<.001	.008	3	3
LIHC	RNU6-618P →	+0.390	+4.014	<.001	.004	3	2
LIHC	RPL36AP51 →	+0.216	+3.856	<.001	.008	3	2
LIHC	RNU6-922P →	+0.236	+5.584	<.001	.001	3	2
LGG	COX6CP5 →	+0.176	+4.987	<.001	.009	3	2
UCEC	LRRC57 →	+0.348	+2.329	.005	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,736 associations by consensus.

RNU6-236P by GADL1 expression — LUSC

Explore this box plot interactively →