GADL1

Across TCGA pan-cancer cohorts, GADL1 RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated GADL1 data layer compared with 11 for mutation status.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher GADL1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated GADL1 expression acts as an unfavorable survival marker, although some lineages such as ACC and SCLC show a favorable association.

SKCM, KIRP, and ACC are the cancer types where GADL1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	OS	Quartile	II,III,IV	0.590	0.763	<.001	85	view →
KIRP	DFS	Median	All	0.415	0.729	<.001	81	view →
ACC	DFS	Tertile	All	0.685	0.274	<.001	67	view →
OV	OS	Median	All	0.778	0.885	<.001	46	view →
SCLC	OS	Median	All	0.849	0.563	.002	39	view →
UVM	DFS	Median	III,IV	0.200	0.892	.001	20	view →
COAD	OS	Tertile	IV	0.790	0.496	.006	17	view →
KICH	OS	Tertile	II,III,IV	0.731	0.952	.014	12	view →
ESCA	DFS	Tertile	III,IV	0.593	0.268	.018	12	view →
HNSC	OS	Median	III,IV	0.181	0.405	.011	10	view →
CHOL	DFS	Tertile	IV	0.122	0.791	.045	9	view →
UCS	DFS	Median	II,III,IV	0.446	0.171	.036	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

GADL1–SKCM (OS)

Open the SKCM breakdown →