GADL1

Across TCGA cell cohorts, GADL1 mutation is significantly associated with the RNA expression of many other genes, with 18 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GADL1-associated genes across cancer lineages are CCDC54, SAXO1, and BPIFB6. Each is linked with GADL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both GADL1-to-partner and partner-to-GADL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CCDC54 grouped by GADL1-low versus GADL1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GADL1→partner) and Y-score (partner→GADL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CCDC54 →	+0.141	+3.447	<.001	.006	3	1
LARGE_INTESTINE	SAXO1 →	+0.040	+3.556	.004	.007	3	1
LARGE_INTESTINE	BPIFB6 →	+0.014	+3.700	<.001	.009	3	1
LARGE_INTESTINE	ACSM5 →	+0.092	+2.878	<.001	.009	3	1
LARGE_INTESTINE	OR1J2 →	+0.097	+3.514	<.001	.001	3	1
LUNG_SCLC	ASB17 →	+0.026	+5.029	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

CCDC54 by GADL1 expression — LARGE_INTESTINE

Explore this box plot interactively →