GADD45A

Across TCGA pan-cancer cohorts, GADD45A mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated GADD45A data layer compared with 25 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher GADD45A mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated GADD45A expression acts as an unfavorable survival marker, although some lineages such as PDAC show a favorable association.

PDAC, LUAD, and LSCC are the cancer types where GADD45A mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Tertile	II,III,IV	0.984	0.409	.020	5	view →
LUAD	OS	Median	All	0.465	0.916	.024	4	view →
LSCC	DFS	Median	All	0.897	1.000	.031	4	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

GADD45A–PDAC (OS)

Open the PDAC breakdown →