GADD45A

Across TCGA patient cohorts, GADD45A mutation is significantly associated with the RNA expression of many other genes, with 39 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GADD45A-associated genes across cancer lineages are SEPTIN14P19, SSTR5, and PMS2P6. Each is linked with GADD45A in more than 1 cancer types. Because this analysis shows association rather than direction, both GADD45A-to-partner and partner-to-GADD45A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SEPTIN14P19 grouped by GADD45A-low versus GADD45A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GADD45A→partner) and Y-score (partner→GADD45A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SEPTIN14P19 →	+0.039	+4.660	<.001	.003	3	2
UCEC	SSTR5 →	+1.157	+4.093	<.001	<.001	3	1
UCEC	PMS2P6 →	+0.292	+2.863	.001	.009	3	1
BLCA	MIR1237 →	+0.242	+7.640	<.001	.009	3	1
BLCA	RNU6-648P →	+0.233	+7.640	<.001	.009	3	1
BLCA	RNA5SP24 →	+0.258	+7.640	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

SEPTIN14P19 by GADD45A expression — UCEC

Explore this box plot interactively →