GADD45A

Across TCGA cell cohorts, GADD45A RNA expression is significantly associated with the go_rna of many other GO terms, with 5,066 significant associations in total. BONE shows the largest number of these associations.

The most reproducible GADD45A-associated GO terms across cancer lineages are Regulation of peptidyl-serine phosphorylation of STAT protein, Regulation of calcineurin-mediated signaling, and Regulation of calcineurin-NFAT signaling cascade. Each is linked with GADD45A in more than 19 cancer types. Because this analysis shows association rather than direction, both GADD45A-to-partner and partner-to-GADD45A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of peptidyl-serine phosphorylation of STAT protein grouped by GADD45A-low versus GADD45A-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GADD45A→partner) and Y-score (partner→GADD45A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Regulation of peptidyl-serine phosphorylation of STAT protein →	+0.319	+1.887	.001	<.001	3	20
BONE	Regulation of calcineurin-mediated signaling →	+0.183	+1.587	<.001	<.001	3	13
BONE	Regulation of calcineurin-NFAT signaling cascade →	+0.174	+1.587	<.001	<.001	3	13
BONE	Regulation of extrinsic apoptotic signaling pathway via death domain receptors →	+0.164	+1.786	<.001	<.001	3	13
BONE	Positive regulation of intracellular transport →	+0.066	+1.583	<.001	<.001	3	13
BONE	Regulation of cell-substrate adhesion →	+0.132	+1.427	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,066 associations by consensus.

Regulation of peptidyl-serine phosphorylation of STAT protein by GADD45A expression — LUNG_SCLC

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