GAD2

Across TCGA patient cohorts, GAD2 mutation is significantly associated with the total protein of many other genes, with 54 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GAD2-associated genes across cancer lineages are FoxM1, PCNA, and Caspase-7-cleavedD198. Each is linked with GAD2 in more than 3 cancer types. Because this analysis shows association rather than direction, both GAD2-to-partner and partner-to-GAD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by GAD2-low versus GAD2-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GAD2→partner) and Y-score (partner→GAD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	FoxM1 →	+0.272	+3.012	.021	.018	3	4
UCEC	PCNA →	+0.201	+1.925	.003	.004	3	4
UCEC	Caspase-7-cleavedD198 →	+0.737	+2.412	<.001	<.001	3	4
LUAD	Cyclin-B1 →	+0.771	+3.000	<.001	.035	2	4
UCEC	Gab2 →	+0.297	+2.906	.009	.001	3	3
LUAD	Akt_pT308 →	-0.212	-2.459	.033	.020	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 54 associations by consensus.

FoxM1 by GAD2 expression — LUAD

Explore this box plot interactively →