GAD2

Across TCGA cell cohorts, GAD2 mutation is significantly associated with the RNA expression of many other genes, with 418 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GAD2-associated genes across cancer lineages are SLC5A8, TARM1, and PHOX2B. Each is linked with GAD2 in more than 1 cancer types. Because this analysis shows association rather than direction, both GAD2-to-partner and partner-to-GAD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLC5A8 grouped by GAD2-low versus GAD2-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GAD2→partner) and Y-score (partner→GAD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	SLC5A8 →	+0.070	+4.906	<.001	.006	3	1
URINARY_TRACT	TARM1 →	+0.026	+5.087	<.001	.004	3	1
BLOOD_Leukemia	PHOX2B →	+0.018	+4.365	<.001	.002	3	1
BLOOD_Leukemia	SLC35G3 →	+0.053	+3.874	<.001	.005	3	1
BLOOD_Leukemia	INSM2 →	+0.184	+3.769	<.001	.008	3	1
BLOOD_Leukemia	ADIG →	+0.018	+4.984	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 418 associations by consensus.

SLC5A8 by GAD2 expression — OESOPHAGUS

Explore this box plot interactively →