GABRR3

Across TCGA patient cohorts, GABRR3 mutation is significantly associated with the total protein of many other genes, with 53 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GABRR3-associated genes across cancer lineages are eEF2, MEK1, and Shc_pY317. Each is linked with GABRR3 in more than 1 cancer types. Because this analysis shows association rather than direction, both GABRR3-to-partner and partner-to-GABRR3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by GABRR3-low versus GABRR3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GABRR3→partner) and Y-score (partner→GABRR3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.332	+1.736	.007	.007	3	2
UCEC	MEK1 →	+0.435	+2.459	<.001	<.001	3	2
UCEC	Shc_pY317 →	-0.172	-1.736	.001	.007	3	2
UCEC	TFRC →	+0.715	+2.459	<.001	<.001	3	2
UCEC	ASNS →	+0.444	+1.678	<.001	.021	3	2
UCEC	14-3-3_beta →	-0.117	-2.780	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 53 associations by consensus.

eEF2 by GABRR3 expression — UCEC

Explore this box plot interactively →