GABRQ

Across TCGA patient cohorts, GABRQ mutation is significantly associated with the RNA expression of many other genes, with 5,515 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GABRQ-associated genes across cancer lineages are ENPP2, UBE2L3, and KIF20A. Each is linked with GABRQ in more than 3 cancer types. Because this analysis shows association rather than direction, both GABRQ-to-partner and partner-to-GABRQ results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ENPP2 grouped by GABRQ-low versus GABRQ-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GABRQ→partner) and Y-score (partner→GABRQ) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	ENPP2 →	-1.201	-2.405	<.001	.003	3	4
UCEC	UBE2L3 →	+0.354	+4.244	<.001	<.001	3	4
UCEC	KIF20A →	+0.575	+2.662	.001	<.001	3	4
LUAD	CPOX →	+0.384	+2.426	.006	.002	3	3
UCEC	ARID3B →	+0.313	+1.958	.001	.002	3	3
UCEC	LRRC57 →	+0.463	+1.736	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,515 associations by consensus.

ENPP2 by GABRQ expression — SKCM

Explore this box plot interactively →