GABRQ

Across TCGA patient cohorts, GABRQ mutation is significantly associated with the total protein of many other genes, with 47 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GABRQ-associated genes across cancer lineages are Rictor_pT1135, S6, and Caspase-8. Each is linked with GABRQ in more than 2 cancer types. Because this analysis shows association rather than direction, both GABRQ-to-partner and partner-to-GABRQ results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Rictor_pT1135 grouped by GABRQ-low versus GABRQ-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GABRQ→partner) and Y-score (partner→GABRQ) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	Rictor_pT1135 →	+0.155	+2.321	.012	.035	2	3
LUAD	S6 →	-0.330	-2.288	.012	.035	3	2
UCEC	Caspase-8 →	-0.285	-2.115	<.001	<.001	3	2
UCEC	eIF4E →	+0.209	+2.820	.001	.001	3	2
UCEC	MEK1 →	+0.365	+2.662	.001	<.001	3	2
UCEC	S6_pS240_S244 →	+0.312	+2.321	.014	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 47 associations by consensus.

Rictor_pT1135 by GABRQ expression — LUAD

Explore this box plot interactively →