GABRB1

Across TCGA patient cohorts, GABRB1 mutation is significantly associated with the total protein of many other genes, with 51 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GABRB1-associated genes across cancer lineages are Cyclin-E2, ASNS, and Caspase-7-cleavedD198. Each is linked with GABRB1 in more than 3 cancer types. Because this analysis shows association rather than direction, both GABRB1-to-partner and partner-to-GABRB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-E2 grouped by GABRB1-low versus GABRB1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GABRB1→partner) and Y-score (partner→GABRB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-E2 →	+0.119	+1.125	.019	.033	3	4
UCEC	ASNS →	+0.417	+1.874	<.001	.002	3	3
UCEC	Caspase-7-cleavedD198 →	+0.421	+1.321	.018	.012	3	3
UCEC	ERK2 →	+0.192	+1.754	<.001	.001	3	2
UCEC	JNK_pT183_Y185 →	-0.170	-2.321	<.001	<.001	3	2
UCEC	mTOR_pS2448 →	-0.090	-1.664	.046	.019	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 51 associations by consensus.

Cyclin-E2 by GABRB1 expression — UCEC

Explore this box plot interactively →