GABRB1

Across TCGA pan-cancer cohorts, GABRB1 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of GABRB1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where GABRB1 RNA is repressed in tumor relative to normal tissue. In most cancer types GABRB1 is over-expressed in tumor, although a few such as KICH and KIRP show the opposite, repressed pattern.

KICH, KIRP, and KIRC are the cancer types where GABRB1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GABRB1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Male	IV	−0.640	<.001	10	view →
KIRP	Male	All	−0.362	<.001	9	view →
KIRC	Male	All	−0.329	<.001	9	view →
THCA	Male	II,III,IV	−0.156	<.001	8	view →
COAD	All	All	+0.160	.006	4	view →
LUSC	Male	All	+0.223	.034	2	view →
UCEC	All	III,IV	−0.100	.044	2	view →
BRCA	Female	All	−0.082	.002	2	view →
LUAD	Female	III,IV	−0.066	.011	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

GABRB1–KICH

Open the KICH breakdown →