GABRB1

Across TCGA cell cohorts, GABRB1 mutation is significantly associated with the RNA expression of many other genes, with 76 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible GABRB1-associated genes across cancer lineages are CD1C, HDGFL1, and DIRAS2. Each is linked with GABRB1 in more than 1 cancer types. Because this analysis shows association rather than direction, both GABRB1-to-partner and partner-to-GABRB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CD1C grouped by GABRB1-low versus GABRB1-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GABRB1→partner) and Y-score (partner→GABRB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	CD1C →	+0.066	+4.054	<.001	.004	3	2
BLOOD_Leukemia	HDGFL1 →	+0.185	+3.007	<.001	.007	3	2
BLOOD_Leukemia	DIRAS2 →	+0.097	+3.502	<.001	.003	3	2
BLOOD_Leukemia	NKX2-6 →	+0.278	+3.786	<.001	.002	3	2
SKIN	PRORY →	+0.604	+4.688	.001	<.001	3	1
BLOOD_Leukemia	ANXA13 →	+0.054	+3.695	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 76 associations by consensus.

CD1C by GABRB1 expression — SKIN

Explore this box plot interactively →