GABRA4

Across TCGA pan-cancer cohorts, GABRA4 Mutation is linked to patient survival in 7 of 34 cancer types, making it a survival-associated GABRA4 data layer compared with 21 for mass-spec protein.

The strongest signal is observed in breast invasive carcinoma (BRCA), where higher GABRA4 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated GABRA4 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

BRCA, UCEC, and LIHC are the cancer types where GABRA4 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BRCA	OS	Median	All	0.779	0.963	<.001	34	view →
UCEC	DFS	Median	II,III,IV	0.948	0.297	.002	32	view →
LIHC	OS	Median	II,III,IV	0.166	0.719	<.001	27	view →
HNSC	OS	Median	All	0.241	0.713	.002	21	view →
PCPG	OS	Median	All	0.010	0.946	<.001	12	view →
CHOL	OS	Median	All	0.155	0.725	.029	3	view →
SKCM	OS	Median	IV	0.415	0.861	.014	3	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

GABRA4–BRCA (OS)

Open the BRCA breakdown →