GABRA1

Across TCGA patient cohorts, GABRA1 mutation is significantly associated with the total protein of many other genes, with 59 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GABRA1-associated genes across cancer lineages are p27_pT157, TFRC, and eIF4E. Each is linked with GABRA1 in more than 3 cancer types. Because this analysis shows association rather than direction, both GABRA1-to-partner and partner-to-GABRA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p27_pT157 grouped by GABRA1-low versus GABRA1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GABRA1→partner) and Y-score (partner→GABRA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	p27_pT157 →	+0.243	+3.467	<.001	.002	3	3
COAD	TFRC →	+0.708	+3.169	.003	.018	3	3
UCEC	eIF4E →	+0.171	+1.836	.010	.001	3	3
UCEC	INPP4B →	-0.243	-2.584	.016	<.001	3	3
UCEC	Caspase-7-cleavedD198 →	+0.562	+1.300	.002	.034	3	3
LUAD	N-Ras →	+0.113	+3.033	.008	.017	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 59 associations by consensus.

p27_pT157 by GABRA1 expression — COAD

Explore this box plot interactively →