GABRA1

Across TCGA cell cohorts, GABRA1 mutation is significantly associated with the RNA expression of many other genes, with 14 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible GABRA1-associated genes across cancer lineages are RNASE3, TNP2, and KCNK18. Each is linked with GABRA1 in more than 1 cancer types. Because this analysis shows association rather than direction, both GABRA1-to-partner and partner-to-GABRA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNASE3 grouped by GABRA1-low versus GABRA1-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GABRA1→partner) and Y-score (partner→GABRA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	RNASE3 →	+0.068	+4.169	<.001	.008	3	1
CNS	TNP2 →	+0.034	+4.321	<.001	.009	3	1
LUNG_NSCLC_LUAD	KCNK18 →	+0.011	+4.078	<.001	.009	3	1
SKIN	CT45A7 →	+0.250	+3.204	<.001	<.001	3	1
BLOOD_Leukemia	C20orf85 →	+0.042	+4.969	<.001	.003	3	1
BLOOD_Leukemia	SLC35G3 →	+0.036	+4.874	.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

RNASE3 by GABRA1 expression — CNS

Explore this box plot interactively →