GABPA

Across TCGA cell cohorts, GABPA mutation is significantly associated with the mutation status of many other genes, with 3,411 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GABPA-associated genes across cancer lineages are ZNF219, IRX3, and BEGAIN. Each is linked with GABPA in more than 2 cancer types. Because this analysis shows association rather than direction, both GABPA-to-partner and partner-to-GABPA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZNF219 grouped by GABPA-low versus GABPA-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GABPA→partner) and Y-score (partner→GABPA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	ZNF219 →	+4.187	+5.000	.008	.008	1	3
LUNG_NSCLC_LUAD	IRX3 →	+5.772	+5.772	.002	.002	1	3
LUNG_NSCLC_LUAD	BEGAIN →	+5.772	+5.772	.002	.002	1	3
LUNG_NSCLC_LUAD	LY75-CD302 →	+4.772	+5.339	.004	.004	1	3
STOMACH	FOXG1 →	+4.807	+4.807	.008	.008	1	3
STOMACH	HIC1 →	+4.807	+4.807	.008	.008	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,411 associations by consensus.

ZNF219 by GABPA expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →