GABARAPL1

Across TCGA patient cohorts, GABARAPL1 mutation is significantly associated with the total protein of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GABARAPL1-associated genes across cancer lineages are eEF2, FOXO3a_pS318_S321, and GSK-3_pS9. Each is linked with GABARAPL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both GABARAPL1-to-partner and partner-to-GABARAPL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by GABARAPL1-low versus GABARAPL1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GABARAPL1→partner) and Y-score (partner→GABARAPL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.399	+2.999	.008	.035	3	1
UCEC	FOXO3a_pS318_S321 →	-0.136	-2.575	.010	.010	3	1
UCEC	GSK-3_pS9 →	-0.455	-2.321	.008	.033	3	1
UCEC	ACC1 →	+0.413	+3.013	.007	.018	3	1
UCEC	HER2_pY1248 →	-0.225	-2.906	.047	.001	3	1
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.500	+2.222	.020	.011	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

eEF2 by GABARAPL1 expression — UCEC

Explore this box plot interactively →