GABARAPL1

Across TCGA pan-cancer cohorts, GABARAPL1 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated GABARAPL1 data layer compared with 1 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher GABARAPL1 RNA is associated with better overall survival. In most high-consensus cancer types, elevated GABARAPL1 expression acts as an unfavorable survival marker, although some lineages such as UVM and LIHC show a favorable association.

UVM, STAD, and LIHC are the cancer types where GABARAPL1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Tertile	II,III,IV	0.924	0.611	<.001	69	view →
STAD	DFS	Tertile	All	0.218	0.466	.006	38	view →
LIHC	OS	Quartile	II,III,IV	0.894	0.660	.002	37	view →
LGG	OS	Tertile	All	0.931	0.843	<.001	34	view →
SKCM	OS	Quartile	II,III,IV	0.450	0.203	<.001	33	view →
KIRC	OS	Median	All	0.720	0.556	<.001	25	view →
LUAD	DFS	Quartile	III,IV	0.536	0.814	.007	24	view →
HNSC	OS	Median	All	0.619	0.789	.001	23	view →
OV	OS	Quartile	III,IV	0.241	0.353	.001	22	view →
COAD	DFS	Median	IV	0.367	0.593	.012	20	view →
ESCA	OS	Tertile	IV	0.143	0.679	.024	18	view →
MESO	OS	Quartile	All	0.513	0.280	.010	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

GABARAPL1–UVM (OS)

Open the UVM breakdown →