GAB1

Across TCGA patient cohorts, GAB1 mutation is significantly associated with the RNA expression of many other genes, with 5,893 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GAB1-associated genes across cancer lineages are ALG3P1, RNU6-718P, and MIR4764. Each is linked with GAB1 in more than 1 cancer types. Because this analysis shows association rather than direction, both GAB1-to-partner and partner-to-GAB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ALG3P1 grouped by GAB1-low versus GAB1-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GAB1→partner) and Y-score (partner→GAB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	ALG3P1 →	+0.048	+4.071	.008	.001	3	2
CESC	RNU6-718P →	+0.142	+5.263	<.001	.001	3	2
CESC	MIR4764 →	+0.237	+4.020	<.001	.009	3	2
SKCM	C2orf69P1 →	+1.406	+2.845	<.001	.002	3	2
CESC	OR8D1 →	+0.041	+4.020	<.001	.009	3	2
CESC	RNU6-20P →	+0.474	+3.381	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,893 associations by consensus.

ALG3P1 by GAB1 expression — CESC

Explore this box plot interactively →