G6PD

Across TCGA patient cohorts, G6PD mutation is significantly associated with the RNA expression of many other genes, with 5,331 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible G6PD-associated genes across cancer lineages are RNU6-1102P, ACADSB, and SNORA10B. Each is linked with G6PD in more than 2 cancer types. Because this analysis shows association rather than direction, both G6PD-to-partner and partner-to-G6PD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-1102P grouped by G6PD-low versus G6PD-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (G6PD→partner) and Y-score (partner→G6PD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RNU6-1102P →	+1.412	+5.410	<.001	.005	3	3
UCEC	ACADSB →	+0.611	+2.665	<.001	<.001	3	3
UCEC	SNORA10B →	+0.161	+2.093	<.001	.004	3	3
UCEC	MIR6803 →	+0.094	+3.723	<.001	.008	3	2
HNSC	RNA5SP238 →	+0.241	+4.736	<.001	.007	3	2
HNSC	MIR218-1 →	+0.267	+5.608	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,331 associations by consensus.

RNU6-1102P by G6PD expression — LUAD

Explore this box plot interactively →