G6PC

Across TCGA pan-cancer cohorts, G6PC mass-spec protein is linked to patient survival in 1 of 34 cancer types, making it a survival-associated G6PC data layer compared with 25 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher G6PC mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated G6PC expression acts as an unfavorable survival marker, although some lineages such as CCRCC show a favorable association.

CCRCC are the cancer types where G6PC mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Quartile	All	1.000	0.827	.018	16	view →

Pink = unfavorable, green = favorable. Showing the 1 strongest of 1 lineages.

G6PC–CCRCC (OS)

Open the CCRCC breakdown →