G6PC

Across TCGA pan-cancer cohorts, G6PC RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of G6PC’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where G6PC RNA is repressed in tumor relative to normal tissue. In most cancer types G6PC is over-expressed in tumor, although a few such as KIRP and COAD show the opposite, repressed pattern.

KIRP, COAD, and KIRC are the cancer types where G6PC tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in G6PC RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	All	III,IV	−5.738	<.001	11	view →
COAD	All	II,III,IV	−0.875	<.001	11	view →
KIRC	Male	All	−2.305	<.001	9	view →
KICH	Male	II,III,IV	−4.260	<.001	8	view →
THCA	All	II,III,IV	−0.042	<.001	7	view →
CHOL	Female	All	−5.016	<.001	5	view →
LIHC	All	II,III,IV	−1.888	.001	5	view →
STAD	All	IV	−0.033	<.001	3	view →
UCEC	All	IV	+0.139	.047	2	view →
ESCA	Female	All	−0.113	.043	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

G6PC–KIRP

Open the KIRP breakdown →