G6PC

Across TCGA patient cohorts, G6PC protein abundance is significantly associated with the RNA expression of many other genes, with 2,672 significant associations in total. GBM shows the largest number of these associations.

The most reproducible G6PC-associated genes across cancer lineages are MIOX, HMGXB4, and HMOX1. Each is linked with G6PC in more than 1 cancer types. Because this analysis shows association rather than direction, both G6PC-to-partner and partner-to-G6PC results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, G6PC versus MIOX in CCRCC, with a Pearson correlation of 0.33.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (G6PC→partner) and Y-score (partner→G6PC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	MIOX →	+1.482	+0.759	<.001	<.001	3	1
CCRCC	HMGXB4 →	-0.204	-0.817	.004	.001	3	1
CCRCC	HMOX1 →	+0.511	+0.821	.002	<.001	3	1
CCRCC	HDAC10 →	-0.125	-0.718	.003	.002	3	1
CCRCC	PCK2 →	+0.390	+0.774	.006	.001	3	1
CCRCC	PCIF1 →	-0.243	-0.882	.003	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,672 associations by consensus.

G6PC vs MIOX — CCRCC

Explore this scatter interactively →