G6PC

Across TCGA patient cohorts, G6PC mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible G6PC-associated genes across cancer lineages are eEF2, EGFR_pY1173, and FOXO3a_pS318_S321. Each is linked with G6PC in more than 1 cancer types. Because this analysis shows association rather than direction, both G6PC-to-partner and partner-to-G6PC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by G6PC-low versus G6PC-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (G6PC→partner) and Y-score (partner→G6PC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.419	+2.321	.007	.034	3	1
UCEC	EGFR_pY1173 →	+0.077	+2.142	.027	.010	3	1
UCEC	FOXO3a_pS318_S321 →	-0.132	-2.449	.015	.019	3	1
UCEC	Ku80 →	+0.213	+2.128	.039	.010	3	1
UCEC	MIG-6 →	+0.091	+1.598	.035	.044	3	1
UCEC	p38-MAPK_pT180_Y182 →	-0.661	-2.794	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

eEF2 by G6PC expression — UCEC

Explore this box plot interactively →