G6PC

Across TCGA cell cohorts, G6PC mutation is significantly associated with the drug of many other genes, with 4 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible G6PC-associated genes across cancer lineages are AZD5991, GSK2110183B, and Sabutoclax. Each is linked with G6PC in more than 1 cancer types. Because this analysis shows association rather than direction, both G6PC-to-partner and partner-to-G6PC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AZD5991 grouped by G6PC-low versus G6PC-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (G6PC→partner) and Y-score (partner→G6PC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	AZD5991 →	+1.125	+2.649	.002	.046	3	1
LARGE_INTESTINE	GSK2110183B →	+0.623	+2.649	.041	.046	3	1
LARGE_INTESTINE	Sabutoclax →	+0.535	+2.769	.010	.040	2	1
LARGE_INTESTINE	776928 →	+0.725	+2.649	.021	.046	1	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

AZD5991 by G6PC expression — LARGE_INTESTINE

Explore this box plot interactively →