G3BP1

Across TCGA pan-cancer cohorts, G3BP1 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated G3BP1 data layer compared with 24 for mass-spec protein and 2 for mass-spec protein.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher G3BP1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated G3BP1 expression acts as an unfavorable survival marker, although some lineages such as COAD show a favorable association.

BLCA, STAD, and COAD are the cancer types where G3BP1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	OS	Median	All	0.059	0.720	<.001	24	view →
STAD	OS	Median	All	0.003	0.667	<.001	18	view →
COAD	DFS	Median	All	1.000	0.775	.031	2	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

G3BP1–BLCA (OS)

Open the BLCA breakdown →