G3BP1

Across TCGA pan-cancer cohorts, G3BP1 mass-spec protein is linked to patient survival in 2 of 34 cancer types, making it a survival-associated G3BP1 data layer compared with 24 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher G3BP1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated G3BP1 expression acts as an unfavorable survival marker.

CCRCC and PDAC are the cancer types where G3BP1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	III,IV	0.379	0.717	.003	9	view →
PDAC	OS	Quartile	All	0.279	0.555	.021	3	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

G3BP1–CCRCC (DFS)

Open the CCRCC breakdown →