G2E3

Across TCGA pan-cancer cohorts, G2E3 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated G2E3 data layer compared with 28 for mass-spec protein and 1 for mass-spec protein.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher G2E3 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated G2E3 expression acts as an unfavorable survival marker.

BLCA, HNSC, and COAD are the cancer types where G2E3 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	OS	Median	III,IV	0.245	0.686	.005	21	view →
HNSC	OS	Median	II,III,IV	0.196	0.710	.023	9	view →
COAD	OS	Median	All	0.403	0.874	.003	6	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

G2E3–BLCA (OS)

Open the BLCA breakdown →