G2E3

Across TCGA patient cohorts, G2E3 mutation is significantly associated with the total protein of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible G2E3-associated genes across cancer lineages are 14-3-3_beta, eIF4E, and ERK2. Each is linked with G2E3 in more than 1 cancer types. Because this analysis shows association rather than direction, both G2E3-to-partner and partner-to-G2E3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by G2E3-low versus G2E3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (G2E3→partner) and Y-score (partner→G2E3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.098	-3.673	.003	.001	3	2
UCEC	eIF4E →	+0.204	+2.584	.003	<.001	3	2
UCEC	ERK2 →	+0.143	+1.678	.026	.021	3	2
UCEC	ASNS →	+0.415	+2.087	<.001	.005	3	2
UCEC	4E-BP1 →	+0.308	+3.807	<.001	<.001	3	2
UCEC	Cyclin-B1 →	+0.618	+2.415	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

14-3-3_beta by G2E3 expression — UCEC

Explore this box plot interactively →