G2E3

Across TCGA cell cohorts, G2E3 mutation is significantly associated with the drug of many other genes, with 15 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible G2E3-associated genes across cancer lineages are Cytarabine, Methotrexate, and JAK1_8709. Each is linked with G2E3 in more than 1 cancer types. Because this analysis shows association rather than direction, both G2E3-to-partner and partner-to-G2E3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cytarabine grouped by G2E3-low versus G2E3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (G2E3→partner) and Y-score (partner→G2E3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Cytarabine →	+0.746	+2.877	.043	.020	3	1
LARGE_INTESTINE	Methotrexate →	+0.920	+2.807	.019	.046	3	1
LARGE_INTESTINE	JAK1_8709 →	+0.477	+2.871	.010	.021	3	1
LARGE_INTESTINE	50869 →	+0.438	+2.871	.028	.021	3	1
LARGE_INTESTINE	KRAS (G12C) Inhibitor-12 →	+0.542	+2.868	.021	.022	3	1
LARGE_INTESTINE	Bexarotene →	+0.375	+2.745	.049	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

Cytarabine by G2E3 expression — LARGE_INTESTINE

Explore this box plot interactively →