G2E3-AS1

Across TCGA pan-cancer cohorts, G2E3-AS1 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated G2E3-AS1 data layer.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher G2E3-AS1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated G2E3-AS1 expression acts as an unfavorable survival marker, although some lineages such as ESCA and UCS show a favorable association.

KIRP, LIHC, and KICH are the cancer types where G2E3-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Tertile	All	0.399	0.730	<.001	84	view →
LIHC	OS	Quartile	All	0.577	0.736	.003	60	view →
KICH	OS	Tertile	All	0.690	0.982	.002	45	view →
KIRC	DFS	Quartile	III,IV	0.503	0.674	.005	40	view →
ESCA	DFS	Tertile	All	1.000	0.500	.010	30	view →
LUAD	DFS	Tertile	IV	0.434	0.796	.004	30	view →
LGG	DFS	Tertile	All	0.258	0.429	.003	27	view →
BLCA	OS	Median	II,III,IV	0.663	0.751	.012	25	view →
UVM	OS	Tertile	III,IV	0.220	0.872	.025	18	view →
UCEC	DFS	Tertile	All	0.781	0.862	.013	16	view →
UCS	DFS	Median	II,III,IV	0.509	0.233	.017	14	view →
HNSC	DFS	Tertile	All	0.649	0.745	.010	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

G2E3-AS1–KIRP (OS)

Open the KIRP breakdown →