G2E3-AS1

Across TCGA pan-cancer cohorts, G2E3-AS1 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of G2E3-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where G2E3-AS1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types G2E3-AS1 is over-expressed in tumor, although a few such as KIRC show the opposite, repressed pattern.

HNSC, LUSC, and BLCA are the cancer types where G2E3-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in G2E3-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	IV	+1.322	<.001	12	view →
LUSC	Female	II,III,IV	+2.654	<.001	9	view →
BLCA	All	All	+1.118	<.001	9	view →
STAD	All	All	+0.458	.002	5	view →
LUAD	All	All	+0.308	<.001	5	view →
LIHC	All	All	+0.276	<.001	4	view →
BRCA	Female	All	+0.152	.001	4	view →
COAD	All	All	+0.180	.028	2	view →
READ	All	III,IV	+0.055	.008	2	view →
ESCA	All	All	+0.320	.046	1	view →
KIRC	Male	III,IV	−0.005	.043	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

G2E3-AS1–HNSC

Open the HNSC breakdown →