G0S2

Across TCGA pan-cancer cohorts, G0S2 RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated G0S2 data layer compared with 1 for mutation status.

The strongest signal is observed in uveal melanoma (UVM), where higher G0S2 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated G0S2 expression acts as an unfavorable survival marker, although some lineages such as ACC and THCA show a favorable association.

UVM, ACC, and KIRP are the cancer types where G0S2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Median	All	0.314	0.653	<.001	118	view →
ACC	DFS	Median	All	0.755	0.414	<.001	117	view →
KIRP	DFS	Quartile	All	0.463	0.824	.001	68	view →
LGG	OS	Median	All	0.740	0.875	<.001	52	view →
STAD	DFS	Median	All	0.549	0.710	.002	48	view →
KIRC	DFS	Tertile	All	0.749	0.870	<.001	42	view →
THCA	DFS	Quartile	II,III,IV	0.863	0.461	<.001	35	view →
LUSC	DFS	Tertile	All	0.672	0.829	<.001	33	view →
GBM	OS	Quartile	All	0.356	0.558	.005	26	view →
READ	OS	Median	All	0.534	0.836	.013	18	view →
CESC	OS	Quartile	III,IV	0.248	0.644	.021	18	view →
SKCM	DFS	Median	All	0.250	0.153	.005	17	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

G0S2–UVM (DFS)

Open the UVM breakdown →