G0S2

Across TCGA pan-cancer cohorts, G0S2 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of G0S2’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where G0S2 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types G0S2 is over-expressed in tumor, although a few such as KIRP and BRCA show the opposite, repressed pattern.

THCA, KIRP, and BRCA are the cancer types where G0S2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in G0S2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	III,IV	+2.394	<.001	10	view →
KIRP	All	All	−1.880	<.001	10	view →
BRCA	All	III,IV	−4.586	<.001	8	view →
COAD	All	II,III,IV	+1.030	<.001	8	view →
BLCA	Male	All	−1.508	.003	7	view →
KIRC	All	All	−0.995	<.001	6	view →
LUSC	All	II,III,IV	−1.460	<.001	5	view →
UCEC	All	II,III,IV	−1.329	.032	4	view →
PRAD	All	All	−1.656	<.001	2	view →
LIHC	All	All	−0.894	.012	2	view →
CHOL	All	All	−2.096	.012	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

G0S2–THCA

Open the THCA breakdown →