FZD4

Across TCGA cell cohorts, FZD4 mutation is significantly associated with the RNA expression of many other genes, with 17 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible FZD4-associated genes across cancer lineages are ACER1, OR2C1, and PRAMEF20. Each is linked with FZD4 in more than 1 cancer types. Because this analysis shows association rather than direction, both FZD4-to-partner and partner-to-FZD4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACER1 grouped by FZD4-low versus FZD4-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FZD4→partner) and Y-score (partner→FZD4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ACER1 →	+0.079	+3.823	.005	.006	3	1
LARGE_INTESTINE	OR2C1 →	+0.162	+4.047	<.001	.001	3	1
LARGE_INTESTINE	PRAMEF20 →	+0.010	+4.022	<.001	.006	3	1
LARGE_INTESTINE	GUCA1A →	+0.056	+3.841	<.001	.003	3	1
LARGE_INTESTINE	WSCD2 →	+0.134	+3.660	<.001	.005	3	1
LARGE_INTESTINE	CFHR2 →	+0.038	+4.022	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

ACER1 by FZD4 expression — LARGE_INTESTINE

Explore this box plot interactively →