FZD3

Across TCGA cell cohorts, FZD3 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,452 significant associations in total. BONE shows the largest number of these associations.

The most reproducible FZD3-associated GO terms across cancer lineages are Regulation of mitotic cell cycle, embryonic, Positive regulation of double-strand break repair via homologous recombination, and Mitotic DNA damage checkpoint signaling. Each is linked with FZD3 in more than 12 cancer types. Because this analysis shows association rather than direction, both FZD3-to-partner and partner-to-FZD3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of mitotic cell cycle, embryonic grouped by FZD3-low versus FZD3-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (FZD3→partner) and Y-score (partner→FZD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Regulation of mitotic cell cycle, embryonic →	-0.254	-2.102	<.001	<.001	3	13
OVARY	Positive regulation of double-strand break repair via homologous recombination →	+0.090	+1.016	<.001	<.001	3	12
BONE	Mitotic DNA damage checkpoint signaling →	+0.075	+1.121	.003	.001	3	12
BONE	Regulation of heterochromatin formation →	+0.096	+1.279	<.001	<.001	3	12
UPPER_AERODIGESTIVE_TRACT	Positive regulation of double-strand break repair →	+0.074	+0.764	<.001	.001	3	12
BLOOD_Lymphoma	Regulation of RNA stability →	+0.056	+1.089	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,452 associations by consensus.

Regulation of mitotic cell cycle, embryonic by FZD3 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →