FZD3

Across TCGA pan-cancer cohorts, FZD3 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of FZD3’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where FZD3 RNA is repressed in tumor relative to normal tissue. In most cancer types FZD3 is over-expressed in tumor, although a few such as KICH and KIRC show the opposite, repressed pattern.

KICH, COAD, and KIRC are the cancer types where FZD3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FZD3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Male	II,III,IV	−0.884	<.001	9	view →
COAD	Female	II,III,IV	+0.877	<.001	9	view →
KIRC	Male	III,IV	−0.494	<.001	9	view →
UCEC	All	All	+0.956	<.001	6	view →
LUAD	Male	All	+0.893	<.001	6	view →
THCA	Male	All	−0.683	<.001	6	view →
LUSC	All	II,III,IV	+0.709	<.001	5	view →
CHOL	Male	All	+1.046	<.001	2	view →
BRCA	All	IV	−0.310	.013	2	view →
LIHC	All	All	+0.214	.007	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

FZD3–KICH

Open the KICH breakdown →